While we like parties in general, but hotel take-overs would be last on that list. Not only do they tend to be more expensive, we didn't find as many opportunities to play with people other than the ones that went with us than we typically do at house or hotel room parties. If staying for a weekend though it does give a little more time to vet couples if you do find someone.
Another potential downside is, depending on how far away the party was, there may not be much opportuniity to get back together with people we did meet and liked. We went to one that was about a 2 hour drive for us, and as it turned out, met a nice couple that lived 4 hours in the opposite direction from us.
We had (and hopefully will again have) so many local party opportuniities that it's hard to justify anything 50 or more miles away. When we do meet people we like at local parties, there's a greater chance to get back together with them as they tend to be more local themselves.
I can see though where parties can more difficult if you have more rules and/or are more picky. We sometimes do split up at parties, but we always know where the other is at. That and condom use for penetration are pretty much our only rules. We also don't play with married people if we know they're married and cheating, but not a huge deal if it happened. We just wouldn't play again if we found out after.