Let me first say that if your wife thinks that a dozen 20 year old cheerleaders are going to drag you away against your will, that's not going to happen. Dammit.
Back in 2006, I brought up the idea to Mrs. VA. We dove in by going to a hotel takeover in Richmond, VA in February 2007. We had rules. Hard rules and soft rules. It was 5 months before we actually played with anyone.
Hard rules = things are OK or not OK without question. No emotions can change a hard rule that evening. If a hard rule = no fucking anyone, well, that's the way it is, no matter how horny or drunk anyone is. It is completely unfair and unacceptable to bring up modifying a hard rule that night. You must trust each other that hard rules will not be broken or even brought up for discussion. Try to keep them simple and unambiguous.
Soft rules = you need an offline (ie NOT in front of other people and pressure) discussion to change them. If either of you says no, it's a no. No bargaining or arguing.
Will women hit on you? Maybe. If that bothers her THAT much than you need to seek out single guys alone. You can control your behavior but not that of other women.